| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
|
|
|
|
|||||||||||||
|
|
|||||||||||||||
a Catheterisation
Laboratory S Giovanni Hospital, Via N Piccolomini 34, 00165 Rome, Italy, b Istituto Anatomia Patologica, Pavia, Italy
Correspondence to: Dr Prati f.prati{at}libero.it
Accepted 9 January
2001
OBJECTIVE
To test the efficacy of
high frequency intravascular ultrasound (IVUS) transducers in
identifying lipid/necrotic pools in atherosclerotic plaques.
METHODS40 MHz transducers were used
for in vitro IVUS assessment of 12 arterial segments (10 coronary and
two carotid arteries, dissected from five different necropsy cases).
IVUS acquisition was performed at 0.5 mm/s after ligature of the
branching points to generate a closed system. Lipid/necrotic areas were
defined by IVUS as large echolucent intraplaque areas surrounded by
tissue with higher echodensity. To obtain histopathological sections
corresponding to IVUS cross sections, vessels were divided into
consecutive 3 mm long segments using the most distal recorded IVUS
image as the starting reference. Samples were then fixed with 10%
buffered formalin, processed for histopathological study, serially cut, and stained using the Movat pentacrome method.
RESULTS122 sections were analysed.
Lipid pools were observed by histology in 30 sections (25%). IVUS
revealed the presence of lipid pools in 19 of these sections (16%;
sensitivity 65%, specificity 95%).
CONCLUSIONSIn vitro assessment of
lipid/necrotic pools with high frequency transducers was achieved with
good accuracy. This opens new perspectives for future IVUS
characterisation of atherosclerotic plaques.
This article has been cited by other articles:
|
|
 |
|
  F Prati, M Zimarino, E Stabile, G Pizzicannella, T Fouad, R Rabozzi, A Filippini, J Pizzicannella, M Cera, and R De Caterina Does optical coherence tomography identify arterial healing after stenting? An in vivo comparison with histology, in a rabbit carotid model Heart, February 1, 2008; 94(2): 217 - 221. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Revkin, C. L. Shear, H. G. Pouleur, S. W. Ryder, and D. G. Orloff Biomarkers in the Prevention and Treatment of Atherosclerosis: Need, Validation, and Future Pharmacol. Rev., March 1, 2007; 59(1): 40 - 53. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Waxman, F. Ishibashi, and J. E. Muller Detection and Treatment of Vulnerable Plaques and Vulnerable Patients: Novel Approaches to Prevention of Coronary Events Circulation, November 28, 2006; 114(22): 2390 - 2411. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kawasaki, B. E. Bouma, J. Bressner, S. L. Houser, S. K. Nadkarni, B. D. MacNeill, I.-K. Jang, H. Fujiwara, and G. J. Tearney Diagnostic Accuracy of Optical Coherence Tomography and Integrated Backscatter Intravascular Ultrasound Images for Tissue Characterization of Human Coronary Plaques J. Am. Coll. Cardiol., July 4, 2006; 48(1): 81 - 88. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. N. DeMaria, J. Narula, E. Mahmud, and S. Tsimikas Imaging vulnerable plaque by ultrasound. J. Am. Coll. Cardiol., April 18, 2006; 47(8 Suppl): C32 - C39. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Schaar, A. F.W. van der Steen, F. Mastik, R. A. Baldewsing, and P. W. Serruys Intravascular palpography for vulnerable plaque assessment. J. Am. Coll. Cardiol., April 18, 2006; 47(8 Suppl): C86 - C91. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Aoki, A. C. Abizaid, P. W. Serruys, A. T.L. Ong, E. Boersma, J. E. Sousa, and N. Bruining Evaluation of Four-Year Coronary Artery Response After Sirolimus-Eluting Stent Implantation Using Serial Quantitative Intravascular Ultrasound and Computer-Assisted Grayscale Value Analysis for Plaque Composition in Event-Free Patients J. Am. Coll. Cardiol., November 1, 2005; 46(9): 1670 - 1676. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Prati, T. Pawlowski, R. Gil, A. Labellarte, A. Gziut, E. Caradonna, A. Manzoli, A. Pappalardo, F. Burzotta, and A. Boccanelli Stenting of Culprit Lesions in Unstable Angina Leads to a Marked Reduction in Plaque Burden: A Major Role of Plaque Embolization?: A Serial Intravascular Ultrasound Study Circulation, May 13, 2003; 107(18): 2320 - 2325. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Yabushita, B. E. Bouma, S. L. Houser, H. T. Aretz, I.-K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, D.-H. Kang, E. F. Halpern, et al. Characterization of Human Atherosclerosis by Optical Coherence Tomography Circulation, September 24, 2002; 106(13): 1640 - 1645. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. de Korte, M. J. Sierevogel, F. Mastik, C. Strijder, J. A. Schaar, E. Velema, G. Pasterkamp, P.W. Serruys, and A. F.W. van der Steen Identification of Atherosclerotic Plaque Components With Intravascular Ultrasound Elastography In Vivo: A Yucatan Pig Study Circulation, April 9, 2002; 105(14): 1627 - 1630. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.L. de Korte, S.G. Carlier, F. Mastik, M.M. Doyley, A.F.W. van der Steen, P.W. Serruys, and N. Bom Morphological and mechanical information of coronary arteries obtained with intravascular elastography. Feasibility study in vivo Eur. Heart J., March 1, 2002; 23(5): 405 - 413. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
